Main Projects and Clinical Trials
PRESORT and COSENSE projects
In the PRESORT and COSENSE projects, we are trying to find better ways to match colorectal cancer patients with effective anti-cancer treatment. In the PRESORT project we use surgical biopsies from colorectal cancer patients to generate tumoroids, and build a library of tumoroid drug-responses. In the COSENSE project we will use needlebiopsies from patients with metastatic colorectal cancer to generate tumoroids, and will use the tumoroid drug responses to assign patients to first-line chemotherapy treatment.
Cristoffer Sakshaug
DRUGLOGICS and ONCOLOGICS projects
In the DrugLogics project, we develop Boolean models to simulate the internal behavior of cells, such as cancer cells. These models help us explore how cells respond to different drug treatments. As part of the ONCOLOGICS project, we tailor these models to match individual patients’ genetic profiles, allowing us to predict treatment outcomes more accurately. We then compare these predictions to real responses observed in lab-grown cancer models, cell lines or tumoroids, to validate and refine our approach.
Viviam Bermudez Paiva
COSENSE-1 Clinical Trial
In the COSENSE-1 trial we stratify patients with metastatic colorectal cancer to the most promising treatment regimen, based on our tumoroid drug screening. Each patient’s treatment recommendation is highly specific due to the use of patient-derived material from “living biopsies”, enabled by our collaboration with the radiology department. COSENSE-1 is the first functional precision oncology trial in Norway. In the future we will expand the number of possible perturbations in our assay, with the ultimate goal of treating cancer as an individual disease, “providing the right treatment to the right patient”.
Ingrid Aune Bergstrøm